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Jayanath Panyam

577-3761
jpanyam@wayne.edu

Area of Interest
Our group is currently interested in exploring nanotechnology for drug and macromolecular delivery to cells and tissue. We are investigating the use of polymeric nanoparticles for sustained drug/gene delivery to cells. One of the applications is the use of dual-agent nanoparticles, which can simultaneously release two or more therapeutic agents (gene/drug, protein/drug or other combinations) for synergistic activity. For example, nanoparticles can be formulated to release intracellularly a combination of chemotherapeutic agent and sensitizer for synergistic antitumor efficacy. We are also investigating the application of this technology for overcoming tumor drug resistance.

Resources
We are equipped with Eppendorf low speed centrifuge (0.5 ml to 250 ml), Nikon inverted microscope equipped with a CCD camera, Misonix sonicator, Labconco tissue culture hoods, Fisher tissue culture incubator, Biotek absorbance, fluorescence and luminiscence plate reader, Labconco lyophilizer, Orbital shaker, microwave oven, autoclave and microplate washer. We also have a Beckman HPLC system equipped with binary pumps, autoinjector, UV and fluorescence detector, and column heater.

Collaboration Interests:
We are looking two types of collaborators from WSU or at another university in Michigan: one with material testing/engineering background and the other with molecular biology/animal models background.