Dr. Martin Philbert
Toxicology of NanoBioMaterials

University of Michigan

Location: Welcome Center

Education
Ph.D., Neurochemistry/Experimental Neurpathology, London University, 1987
B.Sc. (Hons.), Biology/Chemistry, CCAT, Cambridge, 1984

Research Interest & Projects
Active research activities include experimental neuropathology, nitrocompound-induced encephalopathies, mitochondrial mechanisms in non-neuronal cell death, development of Nano-Optical Chemical Systems for in vivo physiology, and nanostructure-based imaging and treatment of tumors of malignant gliomas.

Magnetically Responsive Optical Nanoprobes (MagRONs) & Systems ( Sponsor: DOD )

Cancer Diagnosis & Therapy with Dynamic Nanoplatforms ( Sponsor: NCI )

Nanoscale Modeling & Sensing on Intracellular Transport ( Sponsor: Keck Foundation )

Role of Astrocyte Mitochondria in Neurotoxicity ( Sponsor: NIH )

Selected Publications
Brasuel, M., Miller, T.J., Kopelman, R. and Philbert, M.A. (2004). Development and biological application of liquid polymer PEBBLEs for measurement of Cl. The Analyst, In Press.

Buck, S.M., Xu, H., Brasuel, M., Philbert, M.A. and Kopelman, R. (2004). Nanoscale probes encapsulated by biologically localized embedding (PEBBLEs) for ion sensing and imaging in live cells. Talanta, In Press.

Leyton, B.E., Sastry, A.M., Wang, H., Sullivan, K.A., Feldman, E.L., Komorowski, T.E. and Philbert, M.A. (2004). Changes in sciatic nerve collagen morphology and distribution in BB rat diabetic neuropathy. J Biomechanics, In Press.

Koo, Y-E.L., Cao, Y., Kopelman, R., Koo, S.M., Brausuel, M. and Philbert, M.A. (2004). Real-time measurements of dissolved oxygen inside live cells by organically modified silicates fluroescent nanosensors. Anal Chem, 76, 2498-2505.

Park, E., Kopelman, R., Brasuel, M. and Philbert, M.A. (2003). Ratiometric optical PEBBLE nanosensors for magnesium ions in viable cells. Anal Chem, 75, 3784-3791.

McQueen, C.A., Mitchell, K.M., Dang, L.N., Chau, B., Tjalkens, R.B. and Philbert, M.A. (2003). Prenatal expression of N-acetyltransferases in C57B1/6 mice. Chemico Biological Interactions, 145, 77-87.

Miller, T.J., Phelka, A.D., Tjalkens, R.B., Dethloff, L.A. and Philbert, M.A. CI-1010-induced opening of the mitochondrial permeability transition pore precedes oxidative stress and apoptosis in SY5Y neuroblastoma cells. Brain Research, 963, 43-56.

Brausuel, M., Kopelman, R., Kasman, I., Miller, T.J. and Philbert, M.A. (2003). Ion concentrations in live cells from highly selective ion correlation fluroescent nanosensors. JIEEE, 1, 288-299.