COVID-19 Research Initiatives

  • COVID-19 Basic research

    PI: Ramesh Babu Batchu, associate professor, Surgery, School of Medicine

    Study Title: Recombinant adeno-associated-based vaccine expressing SARS-CoV-2 Spike protein variant

    Description: This study is to develop prophylactic vaccine to prevent COVID-19. We are using non-pathogenic adeno-associated viral vectors expressing SARS-CoV-2 spike protein variant to develop the vaccine.

     

    PI: Eduard Chekmenev, associate professor, Chemistry, College of Liberal Arts and Sciences

    Study Title: Low-Cost, High-Throughput 3D Pulmonary Imaging Using Hyperpolarized Propane Gas

    Description: We aim to validate the use of new inhalable contrast agent for sub-second 3D functional pulmonary imaging. The study spans from the feasibility of imaging to in vivo validation of lung injury in sheep animal model.

     

    PI: Eduard Chekmenev, associate professor, Chemistry, College of Liberal Arts and Sciences

    Study Title: Novel Functional Pulmonary 3D MRI of Lung Diseases Including COVID-19

    Description: This is a pending application with the DOD CDMRP program. We propose to develop a new imaging modality for ultra-high resolution MRI of pulmonary lung function. This is a competitive renewal of ongoing project in my laboratory to develop new technologies for ultra-fast and low-cost high-throughput functional pulmonary imaging.

     

    PI: Fei Chen, professor, Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences

    Study Title: Environmentally induced mdig enforces expression of COVID-19 receptor CD147

    Description: CD147 is one of the known receptors for SARS-CoV-2 virus. Its expression is partially dependent on mdig through histone methylation and demethylation.

     

    PI: Shooshan Dangoulian, assistant professor, Economics, College of Liberal Arts and Sciences

    Study Title:  Economic Consequences of COVID19 in Detroit

    Description: We are conducted industry level analysis for Detroit and Michigan to understand how worker productivity, earnings, and employment status are affected by the COVID19 mitigation measures. We are using this analysis and other metrics to estimate the impact of the virus and the mitigation measures on the local and state economy.

     

    PI: Qingping Dou, professor, Oncology, Karmanos Cancer Institute and School of Medicine

    Study Title: Disulfiram as a COVID-19 inhibitor

    Description: We have been studying Disulfiram (DSF)/ Copper/Zinc as anticancer agents; DSF has been shown to be a direct inhibitor of COVID-19 most recently.

     

    PI: Steve Firestine, professor, Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences

    Study Title: Drug discovery for agents active against COVID-19 and other emerging diseases

    Description: We are planning to develop and conduct high-throughput and in silico screening for agents that target COVID-19 and other emergent diseases. Synthesis and medicinal chemistry of identified hits will be conducted to enhance potency and ADME properties.

     

    PI: Navanth Gavande, assistant professor, Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences

    Study Title: Repurposing Safe and Effective Clinically Developed Drugs for the Treatment of SARS-COV-2 (COVID-19)

    Project Description: A library of FDA approved drugs will be screened for antiviral activity against SARS-COV-2 (COVID-19). The drugs identified in these screens will be prioritized on the basis of their safety and efficacy profile for further preclinical and clinical studies.

     

    PI: Linda Hazlett, vice dean of Research and Graduate Programs, School of Medicine

    Study Title: Particulates effect response to COVID19

    Description: We hypothesize that PM2.5 (major urban airborne pollutant) will have deleterious effects on propensity for and outcome to COVID-19. We will test effects in vitro using molecular and immunological approaches in tissue cultured cells (corneal, retinal endothelial, macrophages, liver cells). Parameters include cell viability, mitochondrial and cytoplasmic stress responses, DNA damage and inflammasome activation.

     

    PI: Glen Hood, assistant professor, Biological Sciences, College of Liberal Arts and Sciences

    Study Title: Decreases of CO2 levels in Detroit during the "Stay Home, Stay Safe" order in Michigan levels affect interactions between plants and insects

    Description: The project aims to determine if decreases in human activity, and more specifically decreases in the local levels of CO2, affects plant-insect interactions.

     

    PI: Yaoxian Huang, assistant professor, Civil and Environmental Engineering, College of Engineering

    Study Title: Exploring the linkage between air pollution exposure and COVID-19 over Metro Detroit

    Description: We will investigate the air pollution exposure as a possible risk factor for COVID-19 incidences and deaths over Metro Detroit through observations and modeling.

     

    PI: Arun Iyer, assistant professor, Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences

    Study Title: Development of SARS-COV2 spike protein antigen-specific vaccine and therapeutic intervention for improving the memory T cell-based immunity

    Description: We will develop a lipid and amyloid protein based ultra-small nanoparticle (USNP) vaccine containing SARS-COV2 spike antigen and toll-like receptors based adjuvant for achieving sustain and long term immunity. We have well established USNP (diameter of 20-30 nm) platform that will be tailored for simultaneous delivery of SARS-CoV-2 Spike antigen and adjuvant for developing mucosal and systemic immunity against SARS-COV2 spike antigen. On the other hand, we will develop inflammatory macrophage targeting FDA approved drugs, such as Remdesivir for improving the therapeutic benefits of commercially used Covid-19 drug candidates.

     

    PI: J.-P. Jin, professor, Physiology, School of Medicine

    Study Title: Targeting Calponin 2 to Mitigate Pulmonary Fibrosis in COVID-19

    Project Description: An investigation on the effect of reductions of calponin 2 on attenuating pulmonary inflammation and fibrosis caused by SARS-CoV-2 infection.

     

    PI: Ulrike Klueh and Marianna Sadagurski, associate professor/professor, Biomedical Engineering and Biological Sciences, College of Engineering/College of Liberal Arts and Sciences

    Title: Attenuation of COVID-19 associated cytokine storm

    Description: Cytokine storm underlies the multiple organ failure associated with severe COVID-19 infections. This study will assess the efficacy of an FDA approved pharmacological agent's ability to mitigate this cascade in the preclinical murine model.

     

    PI: Ladislau Kovari, professor and associate department chair, Biochemistry, Microbiology, and Immunology, School of Medicine

    Study Title: Discovery and development of direct-acting antivirals of SARS-CoV-2

    Project Description: The research focus is in the area of pre-clinical discovery and development of antivirals for the treatment of COVID-19 that is caused by SARS-CoV-2. The goal of this research is to design and develop a series of small-molecule inhibitors targeting critical viral proteins required for virus replication and thus limiting, eliminating, or preventing SARS-CoV-2 infections in humans.

     

    PI: Li Li, professor, Internal Medicine and Center for Molecular Medicine and Genetics, School of Medicine

    Study Title: Mechanisms of COVID-induced cytokine storm

    Description: Understanding the molecular mechanism of the role of cytoskeleton remodeling in Spike protein-ACE2-induced oxidative stress and inflammation in the initiation and progression of Severe Acute Respiratory Syndrome.

     

    PI: Wanqing Liu, associate professor, Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences and School of Medicine

    Study Title: 1) Role of pathogen and host genome in response to SARS-CoV-2 coronavirus infection. 2)Omics-based biomarkers and risk factors for COVID-19 clinical outcomes among African-American patients.

    Description: The aim of this study is to understand why there are inter-patient differences in response to the SARS-CoV-2 coronavirus infection, especially among African-Americans, a population disproportionately affected by COVID-19. What genomic, proteomic, lipidomic and exposomic markers may be able to distinguish the patients with different outcomes, e.g. disease severity, progression, death etc.

     

    PI: Krishna Rao Maddipati, associate professor, Pathology and Lipidomics Core Facility, School of Medicine

    Study Title: Lipid mediator profile of COVID19 infection

    Description: Both inflammatory and resolution of inflammation mediators derived from polyunsaturated fatty acids are first responders of viral infection. Understanding the dynamics of these lipid mediators in the COVID19 patient cohorts is a highly promising approach to assess the disease and prognosis.

     

    PI: Leslie Monplaisir, professor, Industrial & Systems Engineering, College of Engineering

    Study Title: Medical Surge Capability: Performance Evaluation of Hospital Emergency Department

    Description: We are developing a framework to improve the emergency department’s performance and resource utilization under medical surge (i.e., pandemic) by implementing a data-driven simulation and optimization modeling approach.

     

    PI: Hien Nguyen, Carl Johnson-Pfizer Professor of Chemistry, College of Liberal Arts and Sciences

    Study Title: Development of Glycopolymers to Attenuate COVID-19

    Description: We are testing the ability of our glycopolymer (multiple carbohydrate molecules) to inhibit the binding of virus to ACE2.

     

    PI: Shirley Papuga, associate professor, Environmental Science and Geology, College of Liberal Arts and Sciences

    Study Title: Understanding how COVID-19 social distancing influences urban carbon dynamics

    Description: We will be using our eddy covariance tower data (on the roof top of the physics building), and various carbon emissions data to understand how the social distancing practices implemented in Detroit might be influencing urban carbon dynamics.

     

    PI: Mike Petriello, assistant professor, Institute of Environmental Health Sciences and pharmacology, Division of Research and School of Medicine

    Study Title: Impacts of concomitant viral and chemical pollutant exposures on the maternal metabolome and fetal growth

    Description: Maternal viral infection during pregnancy has been associated with multiple deleterious outcomes in children such as preterm birth and decreased fetal growth, but direct viral transmission to fetuses may not be the predominate mode of action. Emerging evidence now points to associations between other environmental stressors, such as exposure to environmental chemicals, and dysregulated maternal inflammation and decreased fetal growth. Using clinical samples and preclinical models of concomitant exposure, we will study how maternal exposures to environmental pollutants such as PFAS interact with COVID-19 viral infections to increase adverse birth outcomes in offspring.

     

    PI: Mike Petriello, assistant professor, Institute of Environmental Health Sciences and pharmacology, Division of Research and School of Medicine

    Study Title: Impact of exposure to dioxin-like pollutants and Per- and polyfluoroalkyl substances (PFAS) on receptors related to COVID-19

    Description: Using previously collected tissues from chronic and acute toxicological studies using mouse models of atherosclerosis, we will evaluate the effects of multiple persistent organic pollutant chemicals on the expression of known COVID-19 receptors (e.g.,ACE2) and other co-receptors.

     

    PI: Jeffrey Ram, professor, Physiology, School of Medicine

    Study Title: Community detection of COVID-19 disease through SARS-CoV-2 monitoring in sewage

    Description: In addition to infecting the respiratory tract, SARS-CoV-2 is also found in the gastrointestinal tract and feces of most COVID-19 patients and has been detected by PCR in sewage influent at wastewater treatment plants when COVID-19 is prevalent and in one report prior to the first confirmed community case. Our goal is to develop a project entitled "Community monitoring of SAR-CoV-2 in sewage to detect and reduce racial disparities in COVID-19 responses" and to determine if the technique will enable early warning of second and third waves of the disease in Detroit next fall and beyond.

     

    PI: Daniel Rappolee, associate professor, Ob/Gyn and CS Mott Center, School of Medicine

    Study Title: Identifying Covid19 and other viral receptors-susceptibilities in embryonic tissues during pregnancy and how they are affected by hormonal and environmental-urban stress

    Description: Establish stress type- and dose-dependent viral susceptibility of embryonic stem cells and their downstream differentiated cell lineages such as liver, neural, heart cell types and developmentally essential first extra-embryonic differentiated lineage; yolk sac endoderm. [We have shown on two current grants that a control hyperosmotic stress slows stem cell growth and forces a significant increase in two genes necessary for cellular uptake of the Covid19 virus, and that phthalates also slow stem cell growth and putatively upregulate the same two Covid19 viral susceptibility genes.] These studies will show which embryonic and fetal tissues change viral susceptibility based on other urban stressors such as air pollution and maternal stress hormones.

     

    PI: Joseph Roche, assistant professor, Health Care Sciences, Eugene Applebaum College of Pharmacy and Health Sciences

    Study Title: The role of dysregulated bradykinin signaling in COVID-19 respiratory complications

    Description: We are planning to develop basic, translational, and clinical studies, to test the hypothesis that dysregulated bradykinin signaling is a target for therapies to treat COVID-19 respiratory complications.

     

    PI: Steven Stack, professor, Criminal Justice, College of Liberal Arts and Sciences

    Study Title: Suicide risk & prevention during the COVID-19 pandemic

    Description: This was just published online at THE LANCET. Lead author is David Gunnell of the UK. It reviews risk factors apt to drive the suicide rate upwards. I have two other projects in progress.

     

    PI: Paul Stemmer, associate professor, Institute of Environmental Health Sciences, School of Medicine

    Study Title: Protein biomarkers of viral infection.

    Description: Evaluate plasma for changes in the proteome in viral positive and negative people.

     

    PI: Zhe Yang, associate professor, Biochemistry, Microbiology, and Immunology, School of Medicine

    Study Title: A Quantitative Network Model for Coronavirus Cross-Species Transmissibility Prediction

    Project Description: The goal of this project is to construct a quantitative mathematical model to predict coronavirus cross-species transmissibility. Our hypothesis is that structure-based mathematical modeling of ACE2-Spike interactions at a species- and strain-wide level will provide a predictive framework for cross-species transmissibility, facilitating epidemic surveillance and identification of potential animal hosts.

     

    PI: Kezhong Zhang, professor, Center for Molecular Medicine and Genetics, School of Medicine

    Study Title: Mechanism of Cytokine Storm in COVID-19 Patients with Metabolic Syndrome

    Description: We propose to define the compositions and dynamics of cytokine storm as well as complex and intertwined molecular events that contribute to cytokine storm in COVID-19 patients with metabolic syndrome.

     

     

  • COVID-19 Behavioral/Social/Educational Research (including clinical study surveys)

    PI: Cynthia Arfken, professor, Psychiatry and Behavioral Neurosciences, School of Medicine

    Study Title: Assessment of Mental Health During the COVID-19 Pandemic in Detroit Healthcare Workers

    Description: Medical Study designed a study to examine mental health of healthcare workers. Dr. Balon is the official faculty advisor and Megan McKenzie is the PI.

     

    PI: Tim Bogg, associate professor, Psychology, College of Liberal Arts and Sciences

    Study Title: Slowing the Spread of COVID-19: Demographic, Personality, and Social Cognition Predictors of Guideline Adherence in a Representative U.S. Sample

    Description: This study examines patterns and psychosocial correlates of adherence to the U.S. governmental guidelines for slowing the spread of COVID-19 using a representative U.S. sample. This research helps clarify the gaps in guideline adherence and highlights individual characteristics associated with those gaps (for preliminary results, please visit: https://psyarxiv.com/yc2gq/).

     

    PI: Krista Brumley, associate professor, Sociology, College of Liberal Arts and Sciences

    Study Title: The Work, Family, and Relationships Study

    Description: The study examines how work-related time constraints and workplace resources (flexible work arrangements)/supervisor support interact over time to influence work-family conflict, mental health, and relationship satisfaction among dual-income couples. The interdisciplinary study uses mixed methods -- surveys and qualitative in-depth interviews.

     

    PI: Rhonda Dailey, assistant professor, Family Medicine and Public Health Sciences, School of Medicine

    Study Title: Biosocial Impact on Black Births (BIBB) Study

    Description: The BIBB study is a prospective, longitudinal, mixed-methods study of pregnant, African American women. Our primary objective is to determine how social stressors alter inflammation during pregnancy and lead to preterm birth in African American women.

     

    PI: Ana Daugherty, assistant professor, Psychology, Psychiatry and Behavioral Neurosciences, Institute of Gerontology, College of Liberal Arts of Sciences, School of Medicine and Division of Research

    Study Title: COVID-19 associated risk for cognitive and neural decline in the elderly

    Description: In an observational, community-based study, COVID-19 diagnosis and symptom severity will be studied as potential risk factors for long-term neural and cognitive declines in middle aged and older adults. Study procedures will include multi-modal MRI, diverse cognitive assessment, and evaluations of potential protective lifestyle factors.

     

    PI: Arash Javanbakht, director, Stress, Trauma and Anxiety Research Clinic, Psychiatry and Behavioral Neurosciences, School of Medicine

    Study Title: Longitudinal study of risk and resilience in healthcare workers and first responders

    Description: Collect baseline trauma/anxiety/depression data, for a longitudinal illness course study, and examining biomarkers of illness course (inflammatory, autonomic), and environment. We also have AR/VR capability for creating treatment scenarios for those traumatized.

     

    PI: Shanhe Jiang, professor and chair, Criminal Justice, College of Liberal Arts and Sciences

    Study Title: Routine Activity Effects of the COVID-19 Pandemic on Burglary in Detroit

    Description: This study examines burglary in 879 block groups of Detroit, Michigan during the month of March, 2020, a period of considerable change in routine activities. The impact of containment policies on burglary clarifies after taking land use into account.

     

    PI: Tanja Jovanovic, professor, Psychiatry and Behavioral Neurosciences, School of Medicine

    Study Title: Detroit Trauma Project: Characterizing Social Support While Under COVID-19 Social Distancing

    Description: Utilizing phone/remote surveys in addition to ecological momentary assessment (EMA; smart-phone based real-time interactions) to capture quantity and quality of social support. We expect that the impact of COVID-19 on mental health outcomes will be moderated by level of social support, including in-person, over phone, or on social media interactions.

     

    PI: Mark Luborsky, professor, Institute of Gerontology and Anthropology, Division of Research and College of Liberal Arts and Sciences

    Study Title: Adherence; primary and secondary prevention. Sequels and long term outcomes (pending)

    Description: Adherence; primary and secondary prevention. Sequels and long term outcomes

     

    PI: Francesca Luca, associate professor, Ob/Gyn and CMMG, School of Medicine, and Samuele Zilioli, assistant professor, Psychology & Family Medicine, College of Liberal Arts and Sciences

    Title: Gene expression responses to the COVID-19 pandemic in African American youth and older adults

    Description: We have been following two cohorts of African Americans (youths and older adults) for the past 8 years. We already have the transcriptomic data prior to the pandemic, we will study changes in their immune cell transcriptional profile after the pandemic, and analyze the role of the psychosocial and physical environment in their response.

     

    PI: Megan McCullen, director, Museum of Anthropology, College of Liberal Arts and Sciences

    Study Title: Material and Cultural Reflections of a Pandemic: COVID-19 in Detroit

    Description: We are collecting material culture, oral histories, personal photographs, digital materials, etc. that reflect the experiences of our campus community and city as it has been transformed through the COVID-19 pandemic. Through collaborative work with Anthropology faculty that have research strengths in Public Health, Urban Anthropology, and Material Culture we will curate community-donated materials so we may process the social impacts in the aftermath of this crisis through analysis and exhibition.

     

    PI: Lucy McGoron, assistant professor – research, Merrill Palmer Skillman Institute for Child & Family Development, Division of Research

    Title: Families C.A.R.E. (Coping Resilience Examination) During COVID-19

    Description: We will examine the impact of school closures and shelter-in-place orders due to COVIID-19 on family functioning, parenting, and children's social, emotional, and behavioral functioning. We are particularly interested in areas that promote resilience against the stress of COIVID-19, such as social and emotional support.

     

    PI: Rahul Mitra, associate professor, Communications, College of Fine, Performing & Communication Arts

    Study Title: Detroit Water Stories: Public Sensemaking of Water Insecurity in Detroit, from Affordability to COVID-19

    Description: This open access project gathers, analyzes and shares oral histories from community members and organizers related to intersections of water insecurity in Detroit, ranging from lack of affordable water billing to recurrent flooding, lead/copper contamination to water infrastructure failures, and spread of water-borne diseases (like Hep-A) to the COVID-19 outbreak.

     

    PI: Seth Norrholm, associate professor, Psychiatry and Behavioral Neurosciences, School of Medicine

    Study Title: Detroit Trauma Project: Characterizing Social Support While Under COVID-19 Social Distancing

    Description: Utilizing phone/remote surveys in addition to ecological momentary assessment (EMA; smart-phone based real-time interactions) to capture quantity and quality of social support. We expect that the impact of COVID-19 on mental health outcomes will be moderated by level of social support, including in-person, over phone, or on social media interactions.

     

    PI: Robert Ty Partridge, associate professor, Psychology, College of Liberal Arts and Sciences

    Study Title: The impact of COVID-19 on vulnerable families

    Description: In order to assess the immediate impact and long-term recovery of the social systemic ramifications of the COVID-19 crisis on vulnerable families in Metro-Detroit, we are extending an ongoing RCT prevention intervention with a sample of 985 families (47% African American, 25% Middle-Eastern). This project assesses 17 domains of family and social stability (e.g., transportation, employment, housing, mental health, etc) as well as social service access and utilization, two years prior to COVID-19, in real time from the onset in March of 2020, and at least through December of 2020 (aiming for December 2021/March 2022).

     

    PI: Jeff Ram, professor, Physiology, School of Medicine and Lance Gable, associate professor, School of Law

    Study Title: Legal and Ethical Implications of SARS-CoV-2 Monitoring

    Description: Testing for SARS-CoV-2, the virus that causes COVID-19, in individuals and in materials that infected people may contaminate, raises many questions about state powers and the ethics of autonomy and justice. Our recent legal and ethical analysis has been on these issues with respect to monitoring SARS-CoV-2 in sewage to detect community prevalence of COVID-19, to guide policy on treatment and prevention resources, and to trigger movement restrictions and testing of individuals. A broader analysis may consider similar issues involved with individualized tests and the applicability of these methods to other diseases.

     

    PI: Brad Ray, Center for Behavioral Health and Justice, School of Social Work

    Study Title: Implementation of Tablets for Telehealth in County Jails

    Description: The Center for Behavioral Health and JusticeJ has funding to study the implementation of tablets into 15 jail facilities in Michigan. These tablets will be used to develop a continuum of care for those with behavioral health in these correctional settings. We will be assessing barriers to implementation, tablet utility to correctional health staff, and modalities of implementation.

     

    PI: Matt Seeger, dean and professor, Communication, College of Fine, Performing and Communication Arts

    Study Title: 1). University responses to Covid-19. 2) Informational Needs in Covid 19

    Description: 1. We conducted a study with the CDC during H1N1 to investigate how universities were enacting responses using policies, procedures, structures and behaviors. We are replicating that project in conjunction with the University of Maryland. 2. In conjunction with Wayne County we are deploying a telephone survey of Wayne County residents to examine how residents are responding and what information they seek, from whom, in what format and when.

     

    PI: Hayley Thompson, professor, associate center director, Community Outreach and Engagement, Karmanos Cancer Institute

    Study Title: The Impact of COVID-19 and Social Distancing on Cancer on Prevention, Control, and Management

    Description: The broad goal of the proposed research is to assess how differences in demographics (rural/urban, age, gender, race, educational attainment) will impact engagement in cancer preventive behaviors (e.g., tobacco cessation) and cancer management/survivorship behaviors (e.g., adherence to treatment and surveillance) in the context of COVID-19-related environmental constraints (e.g., social distancing, employment, mental health, etc.). This research will be conducted among the general adult population, cancer patients, and cancer survivors within Karmanos Cancer Institute’s 46-county catchment area in Michigan.

     

    PI: Angela Jacques Tiura, assistant professor-research, Family Medicine & Public Health Science, School of Medicine

    Study Title: Women's Experiences (WE - Phase 2) in the Time of COVID

    Description: The WE Study will examine WSU women students' eating, drinking, interpersonal violence victimization, and COVID-19 related attitudes, experiences, and beliefs. Among eligible participants, the Phase 2 part includes a daily online component to explore reducing heavy drinking and loss-of-control eating.

     

    PI: Stephanie Tong, associate professor, Communication, College of Fine, Performing & Communication Arts

    Study Title: Racism and Resilience of Pandemic Proportions: Documenting Awareness, Effects, and Reactions to Cyberhate and Harassment During the Covid-19 Outbreak

    Description The origination of the coronavirus in Wuhan, China has led to a xenophobic response here in America. Between March 19 to April 1, over 1,100 reports of hate and harassment were made by Asian Americans. Such numbers reflect the vilification of Asians in America, whom many blame as the cause of the coronavirus. In a two-phase mixed methods study, we aim to understand how the xenophobic reaction to the Covid-19 pandemic is being perceived among Asian Americans and within the larger American population; and to explore the immediate and potential long-term impacts on those are the receiving end of this treatment.

     

    PI: Elizabeth Towner, assistant professor, Family Medicine & Public Health Sciences, School of Medicine

    Study Title: Building Capacity of Detroit Families for Healthy Equity and Outcomes Research Related to COVID-19

    Description: This project aims to adapt our capacity building approach (e.g., form action councils, adapt capacity building curriculum) to increase capacity of community members for pediatric/family-based research specific to health equity and the impact of COVID-19. This application will be submitted to PCORI/parallels a similar application that is focused on adults from Dr. Hayley Thompson.

     

    PI: Dongziao Zhu, associate professor, Computer Science, College of Engineering

    Study Title: COVIDRiskNearMe: A crowdsourcing web-portal for COVID-19 risk self-assessment and geomapping risk stratification

    Description: It is a crowd sourcing web portal to allow self-assessment of COVID-19 risks via questionnaire and display aggregated risk stratification counts on the map.

     

    PI: Rick Zimmerman, professor and associate dean for research, Office of Health Research, College of Nursing

    Study Title: COVID-19, News Perceptions, Risk and Preventive Behaviors, and Health Outcomes

    Description: We will purchase ads to disseminate an anonymous Facebook survey in four areas of the US: Wayne County, Michigan; New Orleans metro area, Louisiana; the Albany, GA area; and Blaine County, Idaho.

     

  • COVID-19 Clinical Trials/Clinical Research

    PI: Asfar Azmi, assistant professor, Oncology, School of Medicine/Karmanos Cancer Institute

    Study Title: Clinical Trial on Selinexor for COVID-19 treatment

    Description: Karmanos clinical team (led by Dr. Geoffrey Zonder) is going to start a clinical study using nuclear export inhibitor selinexor for patients with COVID-19. This trial is based on work done previously in Asfar Azmi's lab that led to several clinical trials at Karmanos and FDA approval of the drug for multiple myeloma.

     

    PI: Tamara Hew Butler, associate professor, Kinesiology, Health and Sport Studies, College of Education

    Project Title: Project SWEAT (Surveillance of Wise re-Entry of Athletes to Training)

    Description: Aim 1: Is SARS-CoV-2 or antibodies transmissible in sweat? Aim 2: Surveillance of athletes with and without SARS-CoV-2 antibodies over training/season.

     

    PI: Lawrence Crane, professor, Internal Medicine, School of Medicine

    Study Title: COVID-19 infection in Persons Living with HIV Infection; a Case-Control Study

    Description: Propose to compare the course and outcome of COVID-19 in PLWHs compared to an infected case control. Hopefully would like to collaborate with several medical centers in the tricounty area.

     

    PI: Mark Favot, associate professor, Emergency Medicine, School of Medicine

    Title: Defining COVID-19 Myocardial Dysfunction

    Project Description: Observational study of patients with confirmed or suspected COVID-19 who have elevated serum troponins. Patients will undergo two focused echocardiograms, one within 24 hours of admission and the second one performed approximately 48 hours after the first exam. Analysis will include description of echocardiographic findings and comparison with patient oriented outcomes including mortality, ICU LOS and ventilator free days.

     

    PI: Phillip Levy, the Edward S. Thomas Endowed Professor and associate chair of research, Department of Emergency Medicine, and assistant vice president for translational science and clinical research innovation,

    Description: This project aims to assess the post-recovery effects of COVID-19 infection and stress on cardiovascular health among first responders and frontline health care workers. The proposed study will aim to address what the impact of COVID-19 infection on heart health will be eight to 10 months after recovery, and the relationship between COVID-19 and heart health moderated by perceived stress or stress-related mental health disorders (e.g., major depressive disorder or post-traumatic stress disorder).

     

     

  • COVID-19 Diagnostics

    PI: Domenico Gatti, associate professor, Biochemistry, Microbiology and Immunology, School of Medicine

    Study Title: AI-imaging based prediction and follow-up of COVID19 infection outcome

    Description: Artificial Intelligence (AI) methods will be used to evaluate various forms of medical imaging (X-ray, CT, MRI) as early indicators of COVID19 infection outcome, and of late complications.

     

    PI: Mark Haacke, Radiology, School of Medicine

    Study Title: Long-term neurological effects of COVID-19

    Description: One concern with COVID-19 is the potential to produce a cytokine storm in the brain. Our goal is to image recovered patients to look for vascular damage to the brain.

     

    PI: John SantaLucia, Jr., professor, Chemistry, College of Liberal Arts and Sciences

    Study Title: Design and Development of multiplexed PCR assays for COVID-19 and other pathogens

    Description: We design multiplexed PCR assays with high sensitivity, high specificity, and low limit of detection for respiratory pathogen panels including: COVID-19, other human coronaviruses, Influenza A, influenza B, RSV A and B, HMPV, HRV A B, PIV 1-4, HEV, hAdV B C E, as well as bacterial pathogens.

     

    PI: Hamid Soltanian-Zadeh, professor, Radiology, School of Medicine

    Study Title: AI-Based Analysis of COVID-19 Images

    Description: Artificial intelligence-based analysis of CT and chest radiography (CXR) for diagnosis, treatment evaluation, and prognosis of COVID-19.

     

    PI: Dongxiao Zhu, associate professor, Computer Science, College of Engineering

    Study Title: COVID-MobileXpert: On-Device COVID-19 Screening using Snapshots of Chest X-Ray

    Description: A lightweight deep neural network based mobile app that can use noisy snapshots of chest X-ray for point-of-care COVID-19 screening

     

     

  • COVID-19 Information Sciences

    PI: Weisong Shi, professor, Computer Science, College of Engineering

    Study Title: CORPUS: An Edge Intelligence-Assisted Multi-Granularity COVID-19 Risk Predication and Update System

    Description: CORPUS is a risk prediction and update system that aims to (1) reduce the anxiety for people and organizations; (2) assess the spread risk of COVID-19; (3) provide prevention strategy at the first time.