Funding Opportunity Notice - NIH Shared Instrumentation/High-End Instrumentation Grant Programs (S10)

Below is information on upcoming biomedical equipment funding opportunities through the National Institutes of Health (NIH). The programs listed below are linked to the sponsor’s program announcements. Be sure to read through the program guidelines carefully to assess fit and eligibility.  

In order to ensure alignment with development of interdisciplinary research programs and core facilities, to address University instrument needs, and to prevent overlap/duplication in proposal submissions from Wayne State University, the OVPR will be administering this opportunity and will provide resources to support the development and preparation of proposals, including internal and external proposal reviews.  While there is no limit on the number of applications an institution may submit, provided the applications are for different types of equipment, the OVPR will review all applications for potential overlap/duplication and coordinate with the PIs to facilitate the preparation of the applications.  

The NIH Office of Research Infrastructure Programs (ORIP)’s S10 Instrumentation Grant Programs support purchases of state-of-the-art commercial instrumentation to enhance research of NIH–funded investigators. Such instruments are typically too expensive for an individual investigator to purchase with a research project grant. Every instrument awarded by an S10 grant is used on a shared basis, which makes the programs cost-efficient and beneficial to thousands of investigators in hundreds of institutions nationwide.

S10 awards are made to domestic public and private institutions of higher education, and non-profit domestic institutions such as hospitals, health professional schools, and research organizations. To be eligible for an S10 award, an institution must identify three or more Principal Investigators with active NIH research awards who demonstrate a substantial need for the requested instrument.

Awards are issued for one year, and matching funds are not required. However, ORIP expects institutions that compete for S10 awards to provide an appropriate level of support for associated infrastructure, such as space to house the instrument, technical personnel, and post-award service contracts for instrument maintenance and operation.

Types of instruments supported by S10 funding include, but are not limited to: X-ray diffraction systems, nuclear magnetic resonance (NMR) and mass spectrometers, DNA and protein sequencers, biosensors, electron and confocal microscopes, cell-sorters, and biomedical imagers.

ORIP manages the S10 programs by issuing Funding Opportunity Announcements (FOAs) with one annual receipt date.

Active FOAs are: 

  • Shared Instrumentation Grant Program (SIG) (S10 Clinical Trial Not Allowed)
    The SIG Program funds grant awards in the $50,000 to $600,000 range.
    (Proposal deadline to NIH: by 5 p.m. EST on June 1, 2022). PAR-22-080
  • High-End Instrumentation Grant Program (HEI) (S10 Clinical Trial Not Allowed)
    The HEI Program funds grant awards in the $600,001 to $2,000,000 range.
    (Proposal deadline to NIH: by 5 p.m. EST on June 1, 2022). PAR-22-079

ORIP encourages applicants to familiarize themselves with the program requirements in these most recent announcements before finalizing their applications so that submitted documents follow the up-to-date guidance on the application content and format.

Visit the S10 Instrumentation Programs website to review what these programs WILL NOT SUPPORT and to ensure ELIGIBILITY. 

Please notify the OVPR by March 15, 2022 if you are planning on submitting an application for this program. Please EMAIL in ONE PDF DOCUMENT the following information to

  • Project title
  • Name, address, phone number, email address, and NIH biosketch of the PD/PI
  • Name, department and school/college, email address, and NIH biosketches of the top 3 users. (Please note: PI may or may not be one of the top 3). 
  • Names of other key personnel, participating departments (school/college)
  • Description of the instrument/equipment requested for upgrade or purchase 

If you have questions on the internal coordination of these opportunities, please contact Denise Figlewicz at

Contact info

Julie O'Connor

Director, Research Communications
Phone: 313-577-8845