Buprenorphine ER versus Ethiqa XR

As a reminder, rodent users currently have two options when providing long-lasting or extended-release opioid pain relief in rodents - either Ethiqa XR or Buprenorphine ER. Below is a comparison of the two drugs:

 

Ethiqa XR

Buprenorphine ER

FDA Approval Status

FDA-Approved

Compounded  

Analgesia Length

Up to 72 hrs

Up to 72 hrs

Dosage

Mouse: 3.25 mg/kg SQ

Rat: 0.65 mg/kg SQ

Mouse: 1-1.2 mg/kg SQ

Rat: 1-1.2 mg/kg SQ

Concentration of vial

1.3 mg/mL

0.5, 1, and 3 mg/mL

Volume of vial

3 mL

5 mL

Shelf Life Unopened

24 months

Typically, 12 months from date of purchase

Shelf Life after Piercing Rubber Seal

90 days

30 days

Cost per vial (subject to change)

$415

$150-190

The compounded Buprenorphine ER medication requires a prescription to be called into Wedgewood pharmacy by Dr. Bradley.  To aid in this process, please provide the following information to Dr. Bradley.

  • Lab DEA License Holder name and address
  • Number of vials (they are 5mL in size)
  • Species
  • Number of animals that will receive the medication
  • Average weight of the animals
  • Average age of the population

Contact info

Julie O'Connor

Director, Research Communications
Phone: 313-577-8845
Email: julie.oconnor@wayne.edu